Gundam Seed

Mobile Suit Gundam SEED (Japanese: 機動戦士ガンダムSEED (シード) Hepburn: Kidō Senshi Gandamu Shīdo?) is an anime series developed by Sunrise and directed by Mitsuo Fukuda. The ninth installment in the Gundam franchise, Gundam SEED takes place in a future calendar era, in this case the Cosmic Era, the first to do so. In this era, mankind has developed into two subspecies: Naturals, who reside on Earth, and Coordinators, genetically enhanced humans capable of amazing feats of intellect who emigrate to man-made orbital colonies to escape persecution by natural humans. The story revolves around a young Coordinator Kira Yamato who becomes involved in the war between the two races after a third, neutral faction's space colony is invaded by the Coordinators. Read more here.

Super Robot Wars IO
In Super Robot Wars IO, Coordinators were made from reverse engineered Protoculture Overtechnology during the Age of the Jaegers. Originally strictly used for the development of DRAUGR and HYDRA super spies and agents, the technology became an open secret after the Suneater War.

Eventually the population of Coordinators became large enough that Naturals started to fear and discriminate against them, leading them to flee from earth to make PLANTS colonies and ZAFT.

Public opinion of them remained low enough that NUNS did not recognize ZAFT as an independent state, nor did they invite them for membership. In particular, Emperor Charles Vi Britannia issued a statement denigrating them as second-class humans, who should have remained a servile race. This made ZAFT embittered towards the so-called 'Earth Alliance' of NUNS, DRAUGR and Britannia.

It was no surprise, then, that they took the chance to strike at the Earth Alliance with the genocide of the Spiral King and Lost Artemis.